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Index > Protein center > MICU1(Gene name) > Human
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  • MICU1 (Gene name),
  • Calcium uptake protein 1, mitochondrial (Protein name ),  MICU1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MICU1(CALC;CBARA1);
    Protein name:
    Calcium uptake protein 1, mitochondrial;
    Alternative:
    Calcium-binding atopy-related autoantigen 1;Atopy-related autoantigen CALC(ara CALC);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MCU.
    Function:
    Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
    Subcellular Location:
    Mitochondrion inner membrane Single-pass membrane protein
    Protein Attributes:
    Sequence length:
    476
    Sequence:
    50:
    MFRLNSLSAL | AELAVGSRWY | HGGSQPIQIR | RRLMMVAFLG | ASAVTASTGL | 
    100:
    LWKRAHAESP | PCVDNLKSDI | GDKGKNKDEG | DVCNHEKKTA | DLAPHPEEKK | 
    150:
    KKRSGFRDRK | VMEYENRIRA | YSTPDKIFRY | FATLKVISEP | GEAEVFMTPE | 
    200:
    DFVRSITPNE | KQPEHLGLDQ | YIIKRFDGKK | ISQEREKFAD | EGSIFYTLGE | 
    250:
    CGLISFSDYI | FLTTVLSTPQ | RNFEIAFKMF | DLNGDGEVDM | EEFEQVQSII | 
    300:
    RSQTSMGMRH | RDRPTTGNTL | KSGLCSALTT | YFFGADLKGK | LTIKNFLEFQ | 
    350:
    RKLQHDVLKL | EFERHDPVDG | RITERQFGGM | LLAYSGVQSK | KLTAMQRQLK | 
    400:
    KHFKEGKGLT | FQEVENFFTF | LKNINDVDTA | LSFYHMAGAS | LDKVTMQQVA | 
    450:
    RTVAKVELSD | HVCDVVFALF | DCDGNGELSN | KEFVSIMKQR | LMRGLEKPKD | 
    476:
    MGFTRLMQAM | WKCAQETAWD | FALPKQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    MIM:
    KEGG:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Calcium uptake protein 1, mitochondrial
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    ELISA Kit for Human Calcium uptake protein 1, mitochondrial
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    ELISA Kit for Human Calcium uptake protein 1, mitochondrial
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    ELISA Kit for Human Calcium uptake protein 1, mitochondrial
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    CLIA Kit for Human Calcium uptake protein 1, mitochondrial
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    CLIA Kit for Human Calcium uptake protein 1, mitochondrial
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    CLIA Kit for Human Calcium uptake protein 1, mitochondrial
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    U15398m
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    Polyclonal Antibody for Human Calcium uptake protein 1, mitochondrial
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    P15398Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Calcium uptake protein 1, mitochondrial
    Polyclonal Antibody for Human Calcium uptake protein 1, mitochondrial
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    P15398Rb-r
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    Polyclonal Antibody for Human Calcium uptake protein 1, mitochondrial
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    P15398Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Calcium uptake protein 1, mitochondrial
    Monoclonal Antibody for Human Calcium uptake protein 1, mitochondrial
    Monoclonal Antibody for Human Calcium uptake protein 1, mitochondrial
    Monoclonal Antibody for Human Calcium uptake protein 1, mitochondrial
    Protein for Human Calcium uptake protein 1, mitochondrial
    Protein for Human Calcium uptake protein 1, mitochondrial
    Protein for Human Calcium uptake protein 1, mitochondrial
    Protein for Human Calcium uptake protein 1, mitochondrial

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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-476 (ISOFORM 2)
      tissue: Kidney.
      tissue: Ovary.
      tissue: Thalamus.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
      tissue: Skin.
    6. 6.
      "Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients."
      Natter S. , Seiberler S. , Hufnagl P. , Binder B.R. , Hirschl A.M. , Ring J. , Abeck D. , Schmidt T. , Valent P. , Valenta R.
      FASEB J.12:1559-1569(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-476 (ISOFORM 1);TISSUE SPECIFICITY;ALLERGEN
    7. 7.
      "Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity."
      Aichberger K.J. , Mittermann I. , Reininger R. , Seiberler S. , Swoboda I. , Spitzauer S. , Kopp T. , Stingl G. , Sperr W.R. , Valent P. , Repa A. , Bohle B. , Kraft D. , Valenta R.
      J. Immunol.175:1286-1294(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    8. 8.
      "MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake."
      Perocchi F. , Gohil V.M. , Girgis H.S. , Bao X.R. , McCombs J.E. , Palmer A.E. , Mootha V.K.
      Nature467:291-296(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-231; GLU-242; ASP-421 AND GLU-432
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter."
      Baughman J.M. , Perocchi F. , Girgis H.S. , Plovanich M. , Belcher-Timme C.A. , Sancak Y. , Bao X.R. , Strittmatter L. , Goldberger O. , Bogorad R.L. , Koteliansky V. , Mootha V.K.
      Nature476:341-345(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MCU
    11. 11.
      "MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival."
      Mallilankaraman K. , Doonan P. , Cardenas C. , Chandramoorthy H.C. , Muller M. , Miller R. , Hoffman N.E. , Gandhirajan R.K. , Molgo J. , Birnbaum M.J. , Rothberg B.S. , Mak D.O. , Foskett J.K. , Madesh M.
      Cell151:630-644(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MCU;MUTAGENESIS OF ASP-231; GLU-242; ASP-421 AND GLU-432
    12. 12.
      "Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic beta-cells."
      Alam M.R. , Groschner L.N. , Parichatikanond W. , Kuo L. , Bondarenko A.I. , Rost R. , Waldeck-Weiermair M. , Malli R. , Graier W.F.
      J. Biol. Chem.287:34445-34454(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MCU
    14. 14.
      "MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca(2+) uniporter."
      Csordas G. , Golenar T. , Seifert E.L. , Kamer K.J. , Sancak Y. , Perocchi F. , Moffat C. , Weaver D. , de la Fuente Perez S. , Bogorad R. , Koteliansky V. , Adijanto J. , Mootha V.K. , Hajnoczky G.
      Cell Metab.17:976-987(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TOPOLOGY
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MCU
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;IDENTIFICATION IN THE UNIPLEX COMPLEX
    17. 17.
      "Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells."
      de la Fuente S. , Matesanz-Isabel J. , Fonteriz R.I. , Montero M. , Alvarez J.
      Biochem. J.458:33-40(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 18.
      "MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter."
      Kamer K.J. , Mootha V.K.
      EMBO Rep.15:299-307(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-231; GLU-242; ASP-421 AND GLU-432
    19. 19.
      "MICU1 and MICU2 finely tune the mitochondrial Ca(2+) uniporter by exerting opposite effects on MCU activity."
      Patron M. , Checchetto V. , Raffaello A. , Teardo E. , Vecellio Reane D. , Mantoan M. , Granatiero V. , Szabo I. , De Stefani D. , Rizzuto R.
      Mol. Cell53:726-737(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MICU2
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MPXPS
    21. 21.
      "Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake."
      Wang L. , Yang X. , Li S. , Wang Z. , Liu Y. , Feng J. , Zhu Y. , Shen Y.
      EMBO J.33:594-604(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 97-476;X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 97-444 IN COMPLEX WITH CALCIUM;SUBUNIT;CALCIUM-BINDING SITES;MUTAGENESIS OF ARG-221; ASP-376 AND 383-PHE--HIS-385
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