Gene name:
MICU1 (CALC;CBARA1) ;
Protein name:
Calcium uptake protein 1, mitochondrial ;
Alternative:
Calcium-binding atopy-related autoantigen 1 ;Atopy-related autoantigen CALC (ara CALC) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MCU.
Function:
Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
Subcellular Location:
Mitochondrion inner membrane
Single-pass membrane protein
Protein Attributes:
50:
MFRLNSLSAL | AELAVGSRWY | HGGSQPIQIR | RRLMMVAFLG | ASAVTASTGL |
100:
LWKRAHAESP | PCVDNLKSDI | GDKGKNKDEG | DVCNHEKKTA | DLAPHPEEKK |
150:
KKRSGFRDRK | VMEYENRIRA | YSTPDKIFRY | FATLKVISEP | GEAEVFMTPE |
200:
DFVRSITPNE | KQPEHLGLDQ | YIIKRFDGKK | ISQEREKFAD | EGSIFYTLGE |
250:
CGLISFSDYI | FLTTVLSTPQ | RNFEIAFKMF | DLNGDGEVDM | EEFEQVQSII |
300:
RSQTSMGMRH | RDRPTTGNTL | KSGLCSALTT | YFFGADLKGK | LTIKNFLEFQ |
350:
RKLQHDVLKL | EFERHDPVDG | RITERQFGGM | LLAYSGVQSK | KLTAMQRQLK |
400:
KHFKEGKGLT | FQEVENFFTF | LKNINDVDTA | LSFYHMAGAS | LDKVTMQQVA |
450:
RTVAKVELSD | HVCDVVFALF | DCDGNGELSN | KEFVSIMKQR | LMRGLEKPKD |
476:
MGFTRLMQAM | WKCAQETAWD | FALPKQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
ELISA Kit for Human Calcium uptake protein 1, mitochondrial
ELISA Kit for Human Calcium uptake protein 1, mitochondrial
ELISA Kit for Human Calcium uptake protein 1, mitochondrial
ELISA Kit for Human Calcium uptake protein 1, mitochondrial
CLIA Kit for Human Calcium uptake protein 1, mitochondrial
CLIA Kit for Human Calcium uptake protein 1, mitochondrial
CLIA Kit for Human Calcium uptake protein 1, mitochondrial
CLIA Kit for Human Calcium uptake protein 1, mitochondrial
Polyclonal Antibody for Human Calcium uptake protein 1, mitochondrial
Polyclonal Antibody for Human Calcium uptake protein 1, mitochondrial
Polyclonal Antibody for Human Calcium uptake protein 1, mitochondrial
Polyclonal Antibody for Human Calcium uptake protein 1, mitochondrial
Monoclonal Antibody for Human Calcium uptake protein 1, mitochondrial
Monoclonal Antibody for Human Calcium uptake protein 1, mitochondrial
Monoclonal Antibody for Human Calcium uptake protein 1, mitochondrial
Monoclonal Antibody for Human Calcium uptake protein 1, mitochondrial
Protein for Human Calcium uptake protein 1, mitochondrial
Protein for Human Calcium uptake protein 1, mitochondrial
Protein for Human Calcium uptake protein 1, mitochondrial
Protein for Human Calcium uptake protein 1, mitochondrial
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-476 (ISOFORM 2)
tissue :
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
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Brain .
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Muscle .
tissue :
Skin .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 167-476 (ISOFORM 1);TISSUE SPECIFICITY;ALLERGEN
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J. Immunol.175:1286-1294(2005)
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-231; GLU-242; ASP-421 AND GLU-432
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.
"Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter."
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Nature476:341-345(2011)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MCU
11.
"MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival."
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Cell151:630-644(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MCU;MUTAGENESIS OF ASP-231; GLU-242; ASP-421 AND GLU-432
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
13.
"MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism."
Mallilankaraman K.
,
Cardenas C.
,
Doonan P.J.
,
Chandramoorthy H.C.
,
Irrinki K.M.
,
Golenar T.
,
Csordas G.
,
Madireddi P.
,
Yang J.
,
Muller M.
,
Miller R.
,
Kolesar J.E.
,
Molgo J.
,
Kaufman B.
,
Hajnoczky G.
,
Foskett J.K.
,
Madesh M.
Nat. Cell Biol.14:1336-1343(2012)
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PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MCU
14.
"MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca(2+) uniporter."
Csordas G.
,
Golenar T.
,
Seifert E.L.
,
Kamer K.J.
,
Sancak Y.
,
Perocchi F.
,
Moffat C.
,
Weaver D.
,
de la Fuente Perez S.
,
Bogorad R.
,
Koteliansky V.
,
Adijanto J.
,
Mootha V.K.
,
Hajnoczky G.
Cell Metab.17:976-987(2013)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TOPOLOGY
15.
"MICU1 motifs define mitochondrial calcium uniporter binding and activity."
Hoffman N.E.
,
Chandramoorthy H.C.
,
Shamugapriya S.
,
Zhang X.
,
Rajan S.
,
Mallilankaraman K.
,
Gandhirajan R.K.
,
Vagnozzi R.J.
,
Ferrer L.M.
,
Sreekrishnanilayam K.
,
Natarajaseenivasan K.
,
Vallem S.
,
Force T.
,
Choi E.T.
,
Cheung J.Y.
,
Madesh M.
Cell Rep.5:1576-1588(2013)
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PubMed ]
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MCU
16.
"EMRE is an essential component of the mitochondrial calcium uniporter complex."
Sancak Y.
,
Markhard A.L.
,
Kitami T.
,
Kovacs-Bogdan E.
,
Kamer K.J.
,
Udeshi N.D.
,
Carr S.A.
,
Chaudhuri D.
,
Clapham D.E.
,
Li A.A.
,
Calvo S.E.
,
Goldberger O.
,
Mootha V.K.
Science342:1379-1382(2013)
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PubMed ]
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;IDENTIFICATION IN THE UNIPLEX COMPLEX
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS OF ASP-231; GLU-242; ASP-421 AND GLU-432
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MICU2
20.
"Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling."
Logan C.V.
,
Szabadkai G.
,
Sharpe J.A.
,
Parry D.A.
,
Torelli S.
,
Childs A.M.
,
Kriek M.
,
Phadke R.
,
Johnson C.A.
,
Roberts N.Y.
,
Bonthron D.T.
,
Pysden K.A.
,
Whyte T.
,
Munteanu I.
,
Foley A.R.
,
Wheway G.
,
Szymanska K.
,
Natarajan S.
,
Abdelhamed Z.A.
,
Morgan J.E.
,
Roper H.
,
Santen G.W.
,
Niks E.H.
,
van der Pol W.L.
,
Lindhout D.
,
Raffaello A.
,
De Stefani D.
,
den Dunnen J.T.
,
Sun Y.
,
Ginjaar I.
,
Sewry C.A.
,
Hurles M.
,
Rizzuto R.
,
Duchen M.R.
,
Muntoni F.
,
Sheridan E.
more...
Nat. Genet.46:188-193(2014)
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Europe PMC ]
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Cited for : INVOLVEMENT IN MPXPS
21.
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Cited for : X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 97-476;X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 97-444 IN COMPLEX WITH CALCIUM;SUBUNIT;CALCIUM-BINDING SITES;MUTAGENESIS OF ARG-221; ASP-376 AND 383-PHE--HIS-385